Methadone is an effective drug, used to eliminate episodes of severe pain. Patients, who require replacement therapy for the opioid dependence treatment, should also buy Methadone.

Methadone belongs to the opioids class. It affects the brain opioid receptors, which modulate and amplify pain signals. Methadone blocks certain opioid receptors, thus raising the pain threshold.

As a drug for opioid substitution therapy (OST), Methadone reduces the patient’s craving for opiates. Regular use of the drug may reduce the dose of opioid analgesics and avoid the emergence of opiates withdrawal symptoms. To save yourself from having to go to a pharmacy, patients in Ireland may buy Methadone online.

Methadone is a fat-soluble component and has a high bioavailability. Penetrating into the body, the drug reaches the maximum plasma concentration in 4 hours. After the first dose, Methadone half-life may vary from 12 to 18 hours. In regular use, the drug concentration in the body reduces by 50% after 13-50 hours after the ingestion.

In Ireland, you may buy Methadone syrup or oral solution. The oral solution is recommended only for use as a replacement therapy. You may buy Methadone syrup as an analgesic or for OST.

Indications for Methadone use as an analgesic:

• chronic disease states;
• severe pain in oncological diseases;
• pain symptoms after surgery.

The initial Methadone dose for the elimination of severe pain symptoms may vary from 5 or 10 mg at once. Regular use of this analgesic requires individual dose adjustment for each patient. Long-term use of the same Methadone doses may reduce its analgesic effect.

In regular Methadone use, this analgesic should not be taken more than twice a day. Due to the long half-life (13-50 hours), frequent use of the analgesic results in its accumulation in the body. Elevated Methadone levels may cause respiratory depression and other adverse reactions.

Benefits of Methadone for relieving the attacks of severe pain:

• it does not cause abrupt changes in the patient’s mental status;
• it has a long half-life, so there is no need for a frequent use during the day;
• it has a longer analgesic effect, compared to other opioid analgesics;
• it can be used to enhance the analgesic effect in combined therapy with non-opioid analgesics;
• long-term use does not cause addiction or dependence, is not toxic.

The initial Methadone dose for getting rid of opioid dependency is selected individually for each patient, and may vary from 10 to 40 mg at once. In regular use, Methadone dose may be increased or decreased by 10 mg per day. A properly chosen dose is the one, which stops craving for opiates, but doesn’t promote euphoria or drowsiness.

Patients, who want to buy Methadone and use it for the replacement therapy, should:

• be aged 18 and more;
• have used opiates for a long time;
• have unsuccessfully tried to stop using opiates at least three times.

Prolonged use of Methadone for opioid dependence treatment has no adverse effect on the internal organs: brain, liver, heart, kidneys, etc. Since both Methadone solution and syrup are taken orally and not intravenously, it eliminates the possibility of infection with HIV, hepatitis and other diseases.

Methadone was not the first opioid analgesic. It was first synthesized in 1939 by Max Bockmhl and Gustav Ehrhart, who worked in the German pharmaceutical company IG Farbenkonzern.

The new substance became known as Hoechst 10820, and then Polamidon, and was created as a replacement for other opiate – Morphine. The official Methadone discovery patent was issued on September 11, 1941. During the six years, following the drug registration, this analgesic was used only in Germany.

In 1947, Polamidon got the name Methadone and started to be used as an analgesic in the UK and the USA. Starting from the first half of the 1960s, the drug was used for the opioid dependence treatment. Since 1992, patients had the possibility to buy Methadone on the Irish pharmaceutical market. The drug has become the major drug for substitution therapy.

In 1993, The Health Service Executive (HSE) has published a Protocol for the Prescribing of Methadone. It contained detailed recommendations for health care professionals on the use of Methadone for substitution therapy. In 1998, the content of the protocol was amended with the guidelines for the fight against opioid dependence.

According to the data as at 2014, more than 10 000 patients in Ireland were using Methadone replacement therapy to get rid of opioid dependence. About a third of the total number of patients (3325 people) used Methadone for 10 years or more.

Today, Methadone remains one of the most demanded opioid analgesics and drugs for OST. According to the data of 2015, the Government of Ireland spent more than € 20 million on Methadone for opioid dependence treatment.

The drug for getting rid of acute and chronic pain symptoms, as well as opioid dependency, is available under different names. Such drugs, as Phymet and Pinadone contain Methadone as the active ingredient. Residents of Ireland will need very little time to place an online order for Methadone.