Tramadol is an effective pain killer that helps get rid of varying severity pain attacks. Patients, exposed to painful symptoms of mild to moderate intensity, as well as chronic pain, may buy Tramadol in Ireland.

Tramadol belongs to analgesic drugs, called “opioid receptor agonists”. The analgesic effect of Tramadol is implemented through the activation of a specific opioid receptors group.

Besides affecting the opioid receptors, Tramadol promotes the inhibition of serotonin and norepinephrine reuptake. Thus, this analgesic exerts not only a central action, but also suppresses pain impulses at the spinal level.

Tramadol has a good bioavailability and is rapidly absorbed. The analgesic effect occurs within 15-30 minutes after the ingestion and lasts 4-6 hours. The maximum plasma concentration is observed 1.5-2 hours after the administration. Tramadol half-life if 4 to 5 hours.

You will not be able to buy Tramadol without a prescription in ordinary drugstore. Besides, this analgesic may simply not be available in the pharmacy chain. Yet, if you order Tramadol online, you will save yourself from the necessity of consulting a doctor and will be able to get this analgesic without a prescription.

When you buy Tramadol online, you simply have to select one of five analgesic dosage forms:

• 50 and 100 mg tablets;
• 50 mg effervescent tablets;
• 100, 150 and 200 mg ER tablets;
• 50 mg/ml and 100mg/2 ml solution for injections/infusions;
• 50, 100, 150 and 200 mg extended release (ER) capsules.

Tramadol dosage depends on the severity and intensity of pain symptoms and the individual drug tolerance. Patients aged 12 to 75 years may take oral forms of this analgesic without dose adjustment. Injectable forms of this opioid may be used for pain management in children aged 1 year and more. To get rid of pain, older patients may need lower Tramadol doses.

Tramadol dose of 50-100 mg every 4-6 hours is usually sufficient for relieving pain symptoms. The initial dose of this opioid analgesic for resolving bouts of acute pain may be Tramadol 100 mg at a time.

The recommended initial Tramadol dose for relieving pain, caused by chronic diseases (arthritis, osteochondrosis) is 50 mg. In subsequent painkiller application, the single dose of Tramadol may be titrated by 50 mg. Regardless of the severity and intensity of pain symptoms, the daily dose of this analgesic should not exceed 400 mg.

If you buy Tramadol for injectable use to eliminate pain, you may introduce this analgesic:

• subcutaneously;
• intravenously;

A single dose of Tramadol for children aged 1 year and more may be 1-2 mg per kilogram of child’s weight. The total daily dose of the analgesic injection solution for children should not exceed 4-8 mg per kilogram of body weight.

Effervescent Tramadol tablets may be convenient for patients, who have difficulty swallowing. Effervescent tablets:

• are easily digested;
• do not require liquid for ingestion;
• increase the bioavailability of the active ingredient.

Patients should begin using this analgesic with the minimum effective dose. The duration of Tramadol use should be as short as possible. The feasibility of further painkiller use should be carefully evaluated on a periodic basis. Avoid taking Tramadol longer than necessary.

To eliminate the pain symptoms, patients may also use combined Tramadol-containing drugs. You may buy combined analgesics in Ireland under such brand names, as Ixprim, Tradol Plus and Skudexa.

Ixprim and Tradol Plus, in addition to the opioid analgesic, also contain Paracetamol – the non-narcotic pain reliever. Each tablet of the combined drugs contains 37.5 mg of Tramadol and 325 mg of Paracetamol. The efficacy of two Ixprim or Tradol Plus tablets is comparable with the use of Tramadol 100 mg. Combined drugs for pain relief lower the risk of side effects, possible during the treatment with this narcotic analgesic.

The drug, called Skudexa, contains the opioid analgesic in conjunction with Dexketoprofen – nonsteroidal anti-inflammatory drug (NSAID). A single Skudexa tablet provides a longer analgesic effect – 8 hours, than Tramadol and Dexketoprofen, used separately (no more than 6 hours).

The advantages of using Tramadol for pain symptoms alleviation:

• dual mechanism of action for pain elimination – over the non-opioid and opioid receptors;
• more rapid achievement of analgesic effect, than after the administration of other opioid analgesics;
• minimum risk of pronounced side effects, characteristic of other central-action opioid analgesics;
• no negative effect over the gastric motility, cardiovascular and respiratory systems;
• low probability of resistance development and drug dependence in prolonged use.

Tramadol may rarely cause insomnia, apathy or dysphoria. Lack of serious adverse reactions of the opioid analgesic allows avoiding concomitant prescription of drugs from other pharmacological classes – benzodiazepines, antidepressants and neuroleptics.

Initially, since its introduction in the medical practice, Tramadol referred to narcotic painkillers. However, numerous experimental and clinical trials have subsequently shown almost a complete lack of ability to cause psychic and physical dependence.

Tramadol is the first opioid analgesic with a unique, dual mechanism of action. It was synthesized in 1962 by the German pharmaceutical company Gruenenthal GmbH. The first Tramadol-based analgesic went on sale in 1977 under the brand name Tramal.

Since the 1970s, Gruenenthal GmbH sold the rights to sell the analgesic to many pharmaceutical companies. Today, Ireland is one of 100 countries in the world, where you may buy Tramadol. Online search for “Tramadol” in Ireland may give such results, as By-Madol, Zydol, Xymel and Tramake. These are the brand names of this opioid analgesic.