Trazodone is an antidepressant from the group of antagonists of postsynaptic serotonin receptors and selective serotonin reuptake inhibitors. This antidepressant has a unique action mechanism and individual clinical and pharmacological effects.
The right to supply Trazodone in Ireland belongs to such companies, as Focus Pharmaceuticals, Sanofi-Aventis and Kinedexe UK. In local pharmacy chains, the Irish may buy Trazodone in form of:
Trazodone is effective both as monotherapy and in combination with other drugs for the treatment of all depression types, including the one accompanied by anxiety. Furthermore, the drug is highly effective in the treatment of depression with sleep disorders.
Trazodone hard capsules may be used for the treatment of depression that caused a sleep disorder. The effectiveness of the insomnia treatment, resulting from the depression or anxiety, depends on how soon the patient begins the drug therapy.
To quickly initiate the depression treatment, accompanied by insomnia and frequent nighttime awakenings, the Irish may buy Trazodone on an online pharmacy.
In general, buying Trazodone online is very beneficial to all potential customers. You may order this antidepressant at any time of the day, because the online pharmacies are usually open round the clock.
Another important aspect is the online Trazodone price, which is usually lower than in the Irish pharmacy chains. This is due to many factors, major of which are the lack of necessity to rent expensive premises and hire a numerous staff.
Direct collaboration with manufacturers and distributors, as well as the minimum extra charges for the antidepressant play another major role in the formation of Trazodone cost on the online pharmacies.
If the patient has never tried using any antidepressants and decides to buy Trazodone without a prescription, he should be aware of the fact that the drug is not recommended for mild depression, which responds well to non-drug treatments.
Due to its unique combination of receptor mechanisms of action, Trazodone exerts a sedative, antidepressant, anxiolytic and antianxiety effects.
Studies have shown that the anxiolytic action mechanism, characteristic of Trazodone, allows prescribing this antidepressant as an alternative to benzodiazepines for the anti-insomnia treatment.
Today, Trazodone is the first (and the only for now) antidepressant from the group of antagonist-inhibitors of serotonin reuptake.
The uniqueness of the drug lies in its dose-dependent clinical effects. Studies show that Trazodone in small doses blocks only a certain subtype of serotonin receptors (5-HT2A) and to a smaller extent – adrenergic receptors and histamine H1-receptors.
The administration of this antidepressant at a daily dose of 50-150 mg does not bring out the antidepressant potential, but effectively eliminates sleep disorders and anxiety.
As the dose increases, the hypnotic effect of Trazodone does not amplify, but a powerful antidepressant effect manifests due to the intensification of serotonin reuptake suppression.
If the patient wants to buy Trazodone on an online pharmacy, he should familiarize himself with the dosing regimen of the antidepressant before he starts using it. The correctness of the dose used affects the safety and efficacy of therapy.
Typically, the initial dose of Trazodone is 50 to 75 mg once a day just before bedtime. The daily Trazodone dose may be increased by 50 mg every 2 days.
The therapeutic dose of this antidepressant ranges from 150 to 600 mg per day. For the elderly, the maximum dose is 300 to 400 mg of Trazodone per day.
Trazodone is easily absorbed from the gastrointestinal tract. However, food slows the absorption rate of the drug. The maximum blood plasma level of the antidepressant is achieved on average one hour after the ingestion. The half-life is 5-9 h.
Trazodone capsules are not recommended to be opened or divided into smaller doses. If the patient finds it difficult to swallow capsules of this antidepressant, he may buy Trazodone oral suspension.
Trazodone oral suspension is supplied to Ireland in glass bottles of 120ml and must be stored in a carton box to protect from light. Each ml of suspension contains 50mg of Trazodone.
Oral suspension has the same antidepressant and anxiolytic activity, like Trazodone film-coated tablets and hard capsules. Therefore, the patient may easily switch from the tablet form of the antidepressant to the oral suspension, if necessary.
Comparative trials on Trazodone with other antidepressants showed that the drug has a favorable safety profile and tolerability.
Unlike modern antidepressants of the selective serotonin reuptake inhibitors class (e.g. Paroxetine, Fluoxetine), Trazodone does not promote the gastrointestinal tract disorders.
Trazodone has a minimum potential for the development of drug dependence and can be used for eliminating benzodiazepines withdrawal symptoms.
Moreover, as an antagonist of the adrenergic α1 receptors, Trazodone does not cause sexual dysfunction, but rather contributes to the recovery of sexual desire and potency.
Trazodone stabilizes patient’s emotional state and improves his mood. The local pharmacy chains and online pharmacies offer Trazodone in Ireland under the trade name Molipaxin.
Today, Trazodone is one of the most effective and safest antidepressants, used in the treatment of patients with anxiety – depressive disorders of the neurotic level.
Trazodone normalizes sleep, increases total sleep time and restores its quality and physiological structure.